Contraindicated (1)pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can decrease panobinostat concentrations by ~70% and produce cure failure. Keep an eye on Carefully (one)pentobarbital will reduce the level or outcome of glecaprevir/pibrentasvir by